施陶丁格反应_百度百科
T1 - Traceless chemical ligation from S -, O -, and N-acyl isopeptides. AU - Panda, Siva S. PY - 2014/4/15. Y1 - 2014/4/15. N2 - Peptides are ubiquitous in nature where they play crucial roles as catalysts (enzymes), cell membrane ion transporters, and … traceless in Chinese | English to Chinese … The traceless Staudinger ligation of azides and phosphines is an effective method to produce an amide bond . 叠氮化合物和膦硫酯的 无 痕施陶 丁格连接反应是一种有效生成酰胺键的方法。 7 The electronic cash is anonymous and traceless. 发行的电子现金具有 Traceless synthesis of ceramides in living cells reveals
Utility of the Phenacyl Protecting Group in Traceless Protein Semisynthesis through Ligation–Desulfurization Chemistry Maria Matveenko, Stefanie Hackl, and Christian F. W. Becker*[a] Semisynthesis of proteins via expressed protein ligation is a
Synthesis, structure determination, and (radio 2011-6-24 · 1. Introduction. In recent years, both the traceless and the non-traceless Staudinger ligation 1 have become important coupling methods for the bioorthogonal interconnection of bioactive molecules2, 2(a), 2(b) as well as in material sciences. 3 Additionally, this ligation was developed as an important approach for the attachment of functional groups like radioactive4, 4(a), 4(b), 4(c) as well Chemoselective Peptide Cyclization by Traceless Staudinger An intramolecular traceless Staudinger ligation was employed to synthesize cyclic peptides. The final amide bond formation was induced by deprotection of the azidopeptide phosphinothioesters. Treatment with trifluoroacetic acid (TFA) results in the simultaneous removal of the borane along with the protecting groups on the peptide side chains
Components of the ligation reaction were prepared as 500 µM solutions in DMEM by diluting stock organic solutions (sphingosine: 40 mM in MeOH and 3i and 4i: 20 mM in l-butanol). The 3i and 4i were added to a final concentration of 100 µM in designated plates and the cells incubated at 37 °C, 5% CO 2 for 4 h, after which sphingosine was added
2020-7-23 · Other Staudinger ligation induced macrocyclizations have been published previously by Maarseveen and co-workers, who successfully used the Raines ligation reagent for the synthesis of a series of medium-sized lactams. 4 Wong and co-workers reported the synthesis of 14 different glycopeptides through the traceless Staudinger Ligation. 5 For this work, they also developed a … A "traceless" Staudinger ligation for the chemoselective 2000-7-13 · A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds. Saxon E(1), Armstrong JI, Bertozzi CR. Author information: (1)Department of Chemistry, University of California, Berkeley, California 94720, USA. Traceless synthesis of ceramides in living cells reveals Components of the ligation reaction were prepared as 500 µM solutions in DMEM by diluting stock organic solutions (sphingosine: 40 mM in MeOH and 3i and 4i: 20 mM in l-butanol). The 3i and 4i were added to a final concentration of 100 µM in designated plates and the cells incubated at 37 °C, 5% CO 2 for 4 h, after which sphingosine was added